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KMID : 0061119840120000059
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Bulletin of the Clinical Research Institute
1984 Volume.12 No. 0 p.59 ~ p.59
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Serum Testosterone,LH and hCG Concentrations in Normal Neonates
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Kim Sang-Bae
Lee Byung-Churl
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Abstract
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Plasma testosterone, LH and β-hCG levels were measured by radioimmunoassay method in 108 healthy male neonates.
Mixed cord blood samples were obtained immediately after cord clamping and other blood specimens were obtained by femoral and external jugular vein puncture at birth, 1, 24, 5-7, 8-10, 11-21 and 22-30 days of life.
The results were as follows;
1. The mean testosterone concentration was a significantly higher in peripheral (2.53±0.15 ng/㎖) than in cord blood (0.730.07 ng/㎖) and dropped within the first 10 days of life (8 to 10 days = 0.60± 0.05 ng/㎖) and a subsequent sharp rise followed (11-14 days = 1.19±0.17; 20-30 days = 2.22±0.21 ng/㎖).
2. The mean LH concentration was higher in cord (19.0±2.7 mIU/㎖) than in peripheral blood (12.5±1.0 mIU/㎖) and decreased within the first 10 days of life (8-10 days = 5.6±1.2 mIU/㎖) and subsequent sharp rise followed (11-14 days = 9.2±1.6; 22-30 days = 11.6±1.7 mIU/㎖).
3. The mean β-hCG concentration was higher in cord (62.5±14.0 mIU/㎖) than in peripheral blood (56.4±10.8 mIU/㎖) and rapidly dropped within the first 5-7 days of life (5-7 days = 8.9±2.0 mIU/㎖) and a nadir from 8 days to 30 days of life.
4. These demonstrate that testicular secretion´ of androgen in already present at birth, and the hCG and LH is likely responsible for the high serum testosterone concentration during the first week of life and the subsequent sharp rise of serum LH.
This would be suggested that the threshold of sensitivity of the gonadostat elevated in neonates.
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